Immediate pericardial protamine administration in acute pericardial tamponade

Abstract Funding Acknowledgements Type of funding sources: None. Aims Cardiac tamponade (CT) is the most common life-threatening complication interventional electrophysiology. Urgent drainage by percutaneous pericardiocentesis and anticoagulation reversal are required. Immediate direct protamine administration to pericardial space patient has not been described. This study was designed assess efficacy safety immediate intrapericardial (IPPA) in CT as a electrophysiologic procedure. Methods A retrospective case series IPPA performed for collected. were achieve hemodynamic stabilization without emergent surgery. Results Eleven cases included two tertiary heart centres. Electrophysiological procedures ventricular tachycardia (n =3), atrial fibrillation = 3), left accessory pathway 1), premature contraction =4) with transseptal 10) and/or retroaortic routes =3). Pericardial all 11 patients. Surgical haemostasis required our cohort. The mean volume drained fluid 486ml (200-1200) Mean dosage 209mg (100-800). systemic 86mg(50-100). No observed on follow-up. Conclusion feasible, safe, useful technique salvage therapy CT. ACT